There are three Spider-Man’s but they all have different storylines. The first Spider-Man movie released in 2002 focused on the standard comic book story, he was bitten by a spider, his uncle died, and he becomes a hero to man haddin. In SpiderMan’s 1-3 he meets characters that becomes his enemies that he has to fight.
Unlike Tobey, This wall crawler has a different path from the comics. In The Amazing Spider-Man peter finds out about his parents and who his dad worked with which is Dr. Connors, He is a more technically advanced than tobey with his mechanical web shooters. In The Amazing Spider-Man 2 the ending takes a really dark turn and his love interest dies.
Our most recent Spidey since Captain America Civil War, Tom Holland is much more interactive with the MCU and there was a strong mentor relationship with Ironman who becomes like a father figure to him. How this spidey’s story ends with no way home, we have seen heavy interaction, lots of science, and with the current Spider-man story, We’ve been introduced to the Multi-verse which gives us new ways for all 3 to interact and new stories that were never in the comics.